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The numerical and structural aberration of chromosomes were analysed from 81 patients who had been doubted as genetic disease in the genetics laboratory, Yonsei University Medical Center from Jan. 1. 1974 to Aug 31. 1975. Out of the 81 patients 39 had the abnormal karyotypes. 13 cases of Down`s syndrome, 4 cases of Turner`s syndrom , 2 cases of Kleinefelter`s syndrome and 19 cases of sex anomaly were found. All kinds of karyotypes observed were ; 1. Down`s syndrome ; primary 21 trisomy type and mosaic type 2. Turner`s syndrome ; 45, X, 46, XX/45, X and 44, X, G/45, X 3. Kleinefelter`s syndrome ; 47, XXY and 48, XXYY 4. Sex anomaly ; XY female and XXmale etc.
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